Does CBD have side effects?
A comprehensive review of the literature covering more than 130 published studies has concluded that, even in cases of high doses of CBD, up to 1500 mg per day, no significant side effects have been reported. There have been no observed alterations in key physiological parameters, such as blood pressure and heart rate, nor significant adverse effects on psychomotor functions in clinical studies.
The few side effects identified, mostly observed in in vitro studies or animal models, include reduced fertility, inhibition of liver enzymes involved in drug metabolism, and changes in cell viability. In human studies, minor side effects reported include diarrhea, fatigue, and changes in appetite, with appetite reduction being more common than an increase.